Tacrolimus treatment for dermatomyositis usually takes about 3 to 6 months to be effective, and some even need to be combined with glucocorticosteroids. As one of the immunosuppressants, tacrolimus is suitable for patients with moderate-to-severe atopic dermatitis, and can relieve a series of symptoms caused by dermatomyositis such as limb weakness. Tacrolimus has a slow onset of action, around 3 to 6 months, and can be tapered off gradually as the disease is gradually controlled. Until the application of the minimum effective dose of maintenance therapy, depending on the specific condition. Adverse reactions such as burning sensation of the skin, itching, flu-like symptoms, and infections can occur with the use of tacrolimus ointment in dermatomyositis. It is contraindicated in patients with a history of hypersensitivity to tacrolimus or any other ingredient in the preparation. care is taken to avoid its use in potentially worsening dermatoses and malignant dermatoses, and it is contraindicated in patients with skin barrier defects. Patients are advised to visit a hospital and treat with medication under the supervision of a doctor, avoiding self-medication.