There are many treatments for dry mouth at night, but due to the different causes of dry mouth at night, such as dehydration, dry mouth syndrome, diabetes, hyperthyroidism, etc., the specific treatment needs to be carried out according to different causes. 1. Dehydration: generally physiological reasons, such as sweating before going to bed after a strenuous exercise without timely replenishment of water, timely replenishment of water can be, without the need for special drugs or other treatment. 2. Dry mouth syndrome: first of all, you can choose to apply artificial saliva to relieve dry mouth, and secondly, you can also follow the doctor’s instructions for the application of hairy fruit rue alkaloids, simethicone and other drugs to stimulate the secretion of saliva, which will help to alleviate the symptoms of dry mouth at night. 3. Diabetes: First of all, you can supplement some water, such as drinking 200ML of warm water before going to bed. Secondly, when the blood sugar drops to normal, the symptoms of dry mouth will be relieved, so you can apply insulin and other drugs for treatment. 4. Hyperthyroidism: for example, applying drugs such as methimazole and propylthiouracil to treat the primary disease, the performance of dry mouth at night will be improved. At the same time can also be appropriate to eat some vegetables, fruits, such as tomatoes, watermelon, etc., are helpful in water supplementation, relieve dry mouth. If the dry mouth at night is difficult to be relieved for a long time, or other discomforts occur, you should consult a doctor in time. Drugs should be used in accordance with medical advice.