Parkinson’s disease is a common neurodegenerative disease in middle-aged and older adults, with onset at age 65 and older. Doctors recognize it mainly by the patient’s motor symptoms. The motor symptoms of Parkinson’s can be described in three words – shaking, stiffness and slow. ”Shaking” means that the patient’s arms and legs or head shake; “stiff” means that the patient’s trunk is very stiff and the facial expression is dull; “slow” means that the patient’s movements are slow, such as The patient’s movements such as dressing, buttoning, walking, etc. are all very slow, and in the later stage, he/she may also have postural balance disorder, walk unsteadily and fall easily. However, in addition to these typical motor symptoms, patients may also experience some non-motor symptoms. Some of them may be sleepy during the day, while others may have trouble sleeping at night, talking in their sleep, shouting, or kicking and punching. Doctors will generally look at patients for these motor symptoms or non-motor symptoms to rank whether they are Parkinson’s disease. Once the condition is diagnosed, the first choice should be medication as a way to replenish the lack of dopamine in the patient’s body, and the patient will need to take the medication for life. In general, the disease can be better controlled with medication in the early stages. When Parkinson’s disease progresses to about 3-5 years, the efficacy of drugs will decrease, and drug side effects will also appear, such as the emergence of allodynia and switch phenomenon, such as patients after taking drugs appear uncontrolled limb writhing, shaped like a dance, or patients due to long-term drug use, symptoms as if there is an invisible switch in the manipulation, often suddenly the whole body stiffness, involuntary movement and even inching difficult to walk condition. In practice, a large number of patients with Parkinson’s disease are safe to take Parkinson’s drugs, and only a small number of patients show changes in liver and kidney indicators as an abnormal reaction to their own liver and kidney disease or special constitution. The risk of taking anti-Parkinson’s disease drugs with necessary monitoring is manageable, and early standardization of medication plays an important role in delaying the progression of Parkinson’s disease and preventing complications due to long-term abnormal posture. Do not simply use the current temporary efficacy to predict the future long-term efficacy of Parkinson’s disease. The “honeymoon” phase of treatment. During the progressive phase of Parkinson’s disease, when the patient’s ability to perform activities of daily living and quality of life are severely impaired by motor complications, the goal of treatment should be to reduce the symptoms of Parkinson’s disease with medication or even surgery, improve motor complications, improve the patient’s quality of life, lower the dose of medication, and reduce the disability rate. Doctors and patients should abandon the view that Parkinson’s disease starts medication only when the symptoms are severe, and consider pacemaker therapy only when medication does not work.