Retinoic acid cream has a certain effect on some hyperplastic or keratotic plaques, or a certain reduction of the effect. Because the retinoic acid cream has a certain exfoliation function, or keratinization function. For some seborrheic keratosis spots still have some efficacy, for some just formed chloasma also has some efficacy, for some pigmentation loss spots, it has no obvious effect. Vitamin A cream in clinical use, mainly depends on this kind of spot belongs to which category. If it belongs to the keratinized plaque, or is relatively mild like flat warts of the spot or have a certain effect.