Papules are formed as a result of tissue-limited hyperplasia or metabolite deposition in the epidermis or dermis. When the skin is stimulated or damaged by various physicochemical factors, an inflammatory reaction will occur and papules can be formed, such as contact dermatitis and seborrheic dermatitis. In addition, various benign and malignant skin tumors formed by local cell overgrowth, such as pigmented nevus and milia, can also cause the formation of papules. If unexplained large pimples appear on the body, you need to consult a doctor in time to determine the cause of the disease with the help of a doctor, and then treat the symptoms.