Gastrointestinal mucosal damage caused by drug factors, mostly seen in gastric mucosa congestion, edema, erosion, excessive secretion of gastric acid, often given acid suppressants and gastric mucosal protective agents, as follows: 1, acid suppressants: acid suppressants can choose H2 receptor antagonists or proton pump inhibitors, proton pump inhibitors including omeprazole, lansoprazole, rabeprazole, pantoprazole, esomeprazole, etc. 2, gastric mucosal protective agents: Gastric mucosal protective agents commonly used aluminum thioglycollate, magnesium aluminum carbonate, bismuth pectin and so on. Drug factors leading to gastrointestinal mucosal damage, should be given to patients at the same time light, warm and soft, easy to digest food, if the drug oral 3-5 days symptoms do not relieve or have aggravated, to immediately go to the hospital for systemic examination, including gastroscopy, to further clarify the site, degree and cause of gastrointestinal damage, to give individualized treatment, to promote recovery, patients are instructed to take standardized medication on weekdays, not private dispensing or increase the amount of drugs used. Systematic treatment should be given under the guidance of a doctor. Do not drink alcohol, do not stay up late, and avoid the intake of spicy and stimulating foods.