With the change of the national family planning policy, two or even three children are gradually recognized, but in the process of conception, there are often unsatisfactory places. The reason I want to write this blog post is the things I encountered, which are regrettable and at the same time, I feel that it is not easy for those who conceive. I met two patients who had seven or eight recurrent miscarriages, but ultimately did not get what they wanted! Thinking about the damage that each miscarriage does to a mother’s heart, isn’t it time to do something for them, or even for the mothers-to-be who may encounter this situation soon! The science, a long way to go. The first case, a few years ago, was seen for abdominal pain and eventually diagnosed with aortitis (mixed type) due to abdominal vascular involvement and eight repeated pregnancies without a viable one. The second case was a patient who was admitted to the hospital with single-digit platelets, a large amount of plasma cavity fluid, severe anemia, proteinuria, and BNP several hundred times higher than normal, and was admitted to the cardiology department in emergency with cardiac insufficiency. Yesterday, we just befriended a patient with two miscarriages within 10 weeks, two biochemicals, and finally an antiphospholipid antibody test with multiple positives and the presence of obstetric APS. There are many patients we met in clinical practice who are engraved and impressed. For connective tissue disease, the disease is controlled and stable, and with the cooperation of rheumatology, obstetrics and pediatrics MDT, they can realize their wish to conceive a small life and have a wonderful family. For different diseases, the requirements are different, such as SLE, indications: 1. stable disease for at least 6 months; 2. prednisone ≤ 10 mg/d; 3. no significant organ involvement; 4. discontinuation of immunosuppression for 3-6 months and LEF for 6 months; Absolute contraindications: 1. severe pulmonary hypertension; 2. progressive heart failure; 3. severe restrictive lung disease; 4. chronic renal failure; 5. Pre-eclampsia or HELLP syndrome despite prior aspirin and heparin therapy; 6. Severe lupus activity or stroke within 6 months. There are also lessons learned in the clinic, once netted for lung transplantation and conception, bringing themselves and their healers into a very passive situation. We also encountered a large number of proteinuric patients secretly pregnant, at more than 16 weeks of gestation, combined with viral infection and fever before coming to follow-up finally 29 + 2 days premature delivery of a baby girl, weighing 1.1Kg, the child is now more than three years old and in good health, although the final outcome is very good, but the process is very bumpy. In clinical practice, there are recurrent oral ulcers, facial erythema, proteinuria, anemia, plasma cavity effusion, Raynaud’s phenomenon, rash, arthralgia, nocturnal back pain, unexplained recurrent miscarriage within 10 weeks of pregnancy, unexplained fetal death after 10 weeks of pregnancy, preeclampsia or placental insufficiency resulting in premature birth within 24 weeks of pregnancy …… may wish to go to the rheumatology Immunology specialist to improve the examination and exclude adverse pregnancy secondary to rheumatologic problems. The presence of rheumatologic problems, active control of the primary disease, the primary disease control and stability, in cooperation with multidisciplinary doctors, will achieve what they want. On the basis of mutual trust, we believe that we will be able to achieve our goal with the company of doctors.