The presence of H. pylori infection in the body does not lead to severe weight loss. H. pylori infection mainly causes acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, and gastric cancer, but it does not directly cause the patient to lose weight. It is possible that the above-mentioned diseases may cause patients to lose appetite or even have poor appetite, which may lead to malnutrition and wasting. Especially for stomach cancer, it is likely to cause the patient to lose weight, but it is a progressive process and will not directly cause the patient to lose weight. If the patient has a significant weight loss within a short period of time, it is necessary to pay attention to exclude whether there is a special wasting disease, especially malignant tumor, and ask the patient to go to the hospital promptly if necessary.