Pain in the middle of the back of the wrist may be caused by physiological factors such as overuse of the wrist, improper pen grip, etc., and generally does not require special treatment. If it is caused by carpal tunnel syndrome, tenosynovitis or other diseases, medication can be taken to treat the symptoms. 1. Physiological factors: excessive use of the wrist, holding the pen in an improper position, may lead to pain in the middle of the back of the wrist. Generally, no special treatment is needed. Appropriate rest and proper pen-gripping posture can relieve the symptoms. 2. Carpal Tunnel Syndrome: Pain in the middle of the back of the wrist may also be caused by carpal tunnel syndrome. Patients can take oral non-steroidal anti-inflammatory drugs, such as aspirin, ibuprofen, etc., under the guidance of the doctor. Steroid hormones such as hydrocortisone and dexamethasone can also be injected into the carpal tunnel to reduce edema in the tissues. 3. Tenosynovitis: pain in the middle of the back of the wrist may also be caused by tenosynovitis. Patients can follow the doctor’s instructions oral or topical aspirin, acetaminophen and other non-steroidal anti-inflammatory drugs, or in the tendon sheath injection of prednisone, dexamethasone and other glucocorticoid drugs, analgesic and anti-inflammatory. Patients with pain in the middle of the back of the wrist are advised to go to the hospital, under the guidance of the doctor, to clarify the cause of the disease, and take relevant treatment measures symptomatically.