Patients always wake up at 4 o’clock in the middle of the night belongs to sleep disorders, early awakening, the main reasons are the following: First, consider the existence of patients caused by neurological weakness, if patients are usually more anxious, nervous, distracted when things are easy to appear the symptoms of always wake up at 4 o’clock in the middle of the night. Second, consider the somatic diseases caused by more than four o’clock in the middle of the night always wake up, patients should pay attention to whether it is because of frequent urination or stomach pain. There is more secretion of stomach acid at four o’clock in the middle of the night, and if the patient has gastroduodenal ulcer, he or she is prone to stomach pain, acid reflux and heartburn, leading to the problem of early waking. Third, patients always wake up at four o’clock in the middle of the night may have a relationship with the usual habits, if patients often wake up at four o’clock in the middle of the night after playing with cell phones resulting in biological clock disorders, also prone to early waking problems.