Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multisystem organ damage and the presence of multiple autoantibodies in the serum. The cause of the disease is unknown and may be related to genetics, sex hormones, environment and immune dysfunction. Early and regular treatment can make the majority of patients’ disease can be effectively controlled, although it cannot be cured, but the current treatment methods and strategies can completely achieve the purpose of no symptoms and survival with disease. 1.Disease control (no symptoms, no evidence of organ damage and normal inflammatory indexes; 2.Basic disease control (no symptoms, basic normal or stable organ damage indexes, normal inflammatory indexes). I. Induction of remission (to achieve the above treatment goals in the shortest possible time) 1. hormones: prednisone, dexamethasone, methylprednisolone and depo-prednisone, etc., are the drugs of choice and are necessary as bridge therapy to rapidly improve symptoms and control the disease, but they have to bear more side effects and are used in high doses for the shortest possible time and reduced as early as possible; 2. intravenous gammaglobulin: immunosuppression has a rapid onset of action and has the effect of increasing The patient’s ability to resist disease. It is often used in critical patients, such as those with important organ damage, low immune function and significantly reduced platelets; 3, immunosorbent and plasma exchange: fast-acting, but easy to rebound and expensive. It is an alternative for critically ill patients, such as those with vital organ damage, organism immunocompromised and significantly reduced platelets, and often plays a crucial role. It can be used for disease control before and during pregnancy; 4. Biological agents: rapid relief and small side effects are its outstanding advantages, and it is an alternate choice in treatment, but it is more expensive and may be ineffective in a small number of patients, and can be chosen if economic conditions allow. Second, maintenance treatment (is to prevent relapse to achieve long-term survival guarantee) 1, hormones: prednisone, methylprednisolone, etc., induction of remission 1 to 2 months after the doctor’s guidance can be reduced, the principle is first fast and then slow, with the dose reduction, the rate of reduction slowed down until a small dose of maintenance, some patients can stop the drug; 2, hydroxychloroquine sulfate: at present, domestic and foreign scholars regard it as a basic drug, with few side effects, pregnancy can be It has certain anticoagulation, anti-infection, hypoglycemic and hypolipidemic effects. Under the guidance of doctors, this drug can be used for a long time and can be discontinued in some patients with stable disease; 3. Immunosuppressants: cyclophosphamide, vincristine, leflunomide, mycophenolate, methotrexate, azathioprine, tacrolimus and cyclomycin, etc. Close follow-up is the key to the treatment of SLE. In principle, patients must be followed up once every three weeks. The follow-up period can be extended according to the condition after 1 year of treatment.