The high activated partial thromboplastin time is mainly caused by coagulation abnormalities. First, the abnormal liver function; because the liver function for the production of thrombin is reduced, the quality of production is not high, therefore, lead to the activation of the partial prothrombin time is prolonged. Second, the cause of drugs; with anticoagulant drugs such as heparin, low molecular heparin, enoxaparin. Thirdly, drugs taken orally, causing high activated partial thromboplastin time. Therefore, it is important to monitor the coagulation when applying anticoagulant drugs to see the value of activated partial thromboplastin time. Usually it is at 1.5 times to stop the anticoagulant. Anticoagulants and thrombolytics should be stopped because if it is elevated to 1.5 times it will cause bleeding and the chances of bleeding will be greatly increased. Therefore, it is important to monitor regularly during the course of the medication. Monitor coagulation on day 1, day 3 and day 5 of medication, and if you find any problems, make sure to treat them promptly.