The side of the thumb hurts when pressed, more commonly due to trauma caused by the side of the thumb related muscle damage, or due to the thumb by abnormal pulling, caused by the side of the thumb injury, and then appear the side of the thumb muscle pain. In addition, excessive gripping with the hand may cause fatigue of the inner muscles of the thumb, and then pain in the lateral aspect of the thumb may occur. Tendonitis, which can be caused by too much thumb activity or incorrect use of the thumb, can also cause muscle pain on the side of the thumb. Prolonged pressure on the wrist or hand can also cause compression of the median nerve at the wrist, which can cause pain in the side of the thumb. Prolonged exposure to cold can also cause muscle pain in the lateral aspect of the thumb, or some people may experience ischemic changes in the lateral aspect of the thumb after bracing their hand on the ground, which can also cause pain in this area. If there is no relief within a short period of time, it is necessary to go to the regular hospital in time to further improve the relevant examination, and choose a reasonable treatment method after clarifying the cause.