Diseases such as testicular inflammation, testicular torsion, testicular cancer and prostatitis can cause swelling and pain in the testicles of men, which can be treated with medication and surgery, etc. 1. Testiculitis: Testiculitis can cause testicular swelling and pain. Antibiotics can eradicate the causative bacteria, and common medications include ceftriaxone and levofloxacin. Painkillers can help relieve the discomfort, and common medications include ibuprofen. 2. Testicular torsion: Doctors can use manipulation to reset the testicle, generally the success rate is not high. If the pain is not reduced after reset, surgery is recommended. Common surgical methods include testicular torsion reset and fixation, orchiectomy. 3. Testicular cancer: mainly treated by surgical resection. Commonly used surgical methods include radical inguinal orchiectomy and laparoscopic surgery. Chemotherapeutic drugs can also be used to kill cancer cells or stop their growth, and commonly used drugs include cisplatin, paclitaxel, cyclophosphamide and so on. 4. Prostatitis: Chronic prostatitis may cause swelling and pain in the testicles. It can be treated with alpha-blockers (terazosin), antibiotics (norfloxacin) and other drugs. There are many causes of testicular distension and pain, it is recommended to visit the hospital for timely treatment. All of the above medications should be applied under the supervision of a doctor.