Liver transplantation is currently the most effective treatment for end-stage liver disease, and the prognosis of the operation is good, but the hazards of liver transplantation mainly include immune rejection and complications after liver transplantation. 1. immune rejection reaction: the transplanted liver is a foreign body, which will cause immune rejection reaction of the body, the hyperacute rejection reaction usually occurs about 24 hours after the operation, the symptom mostly manifests as the liver function damage, and the patient has fever, high fever and other manifestations, at present, for the immune rejection reaction, the patient can take anti-rejection medicines to alleviate the symptoms. 2. Complications after liver transplantation: Complications after liver transplantation include postoperative intra-abdominal hemorrhage, biliary tract complications and infections, the incidence of hemorrhage is relatively small, and coagulants can be used to intervene; biliary tract complications need symptomatic treatment, and antibiotics can be used prophylactically for possible infections. For patients with indications for liver transplantation, it is necessary to improve the relevant examinations to determine whether liver transplantation can be carried out, the benefits and harms of liver transplantation need to maintain a correct understanding of the positive treatment under the guidance of the doctor.