The gold standard for the diagnosis of acute tubular necrosis is renal puncture, which will reveal extensive necrosis of the renal tubules. However, many clinical determinations of acute tubular necrosis are not based on renal puncture because patients are resistant to it. At this time, it can be based on the typical medical history, if the patient has a history of nephrotoxic drugs, such as in a short period of time a large number of applications of antibiotics such as gentamicin, etilmicin, or have rhabdomyolysis, and has been performed relevant examination, to exclude the acute glomerulonephritis, acute interstitial nephritis, as well as post-renal acute renal failure, consider acute tubular necrosis. Acute tubular necrosis is the most common type of acute renal failure, and this type of acute renal failure is very much related to the application of nephrotoxic drugs and rhabdomyolysis. This type of renal failure usually passes through oliguria, polyuria and recovery phase, and most of the patients recover relatively well without sequelae after being given water and electrolyte balance, and hemodialysis treatment if necessary.