Lung adenocarcinoma pain is intolerable, mainly through drug treatment to relieve pain, in addition, if the tumor is controlled, the patient’s pain will also be relieved, so anti-tumor treatment is also needed. For lung adenocarcinoma pain intolerable, it can be treated according to WHO three-step pain relief program. For mild pain, drugs such as acetaminophen and celecoxib can be used to relieve the patient’s pain. For moderate pain, drugs such as aminotramadol and tramadol can be used to control the patient’s pain. For severe pain opioids such as morphine extended-release tablets and oxycodone extended-release tablets can be used to control the patient’s symptoms. In addition, cancer pain is caused by tumor invasion of nerves, patients also need to carry out anti-tumor treatment, such as chemotherapy, radiotherapy, targeted, immunotherapy, etc. to control the tumor, if the tumor is under control, the pain will generally be relieved. In addition, it is recommended to divert attention when in pain, such as listening to music or watching TV to divert attention. When the patient’s pain is serious, he should consult a doctor in time, and the specific use of drugs should be combined with his own situation under the guidance of a professional doctor, do not blindly take on their own.