Our center currently performs PGD/PGS (third generation IVF) using the gene chip method to screen for abnormalities in 23 pairs of chromosomes greater than 5Mb. It is indicated for: chromosomal abnormalities (including balanced translocations, rosette translocations, inversions, deletions, insertions, etc.); advanced age; recurrent miscarriages; recurrent implantation failures; male factor (severe oligospermia). The following conditions are currently required to perform PGD for monogenic diseases in our center: a family history of hereditary diseases, a clear report of diagnosis of monogenic diseases, and genetic verification of patients with the disease in the family (prior witnesses). Couples with these three conditions may be considered for PGD for monogenic diseases.