The main lesions involved in glomerulonephritis are glomeruli, and in a small number of patients, tubules are also involved. The main lesion site of glomerulonephritis is glomerulus, which can be all parts of the glomerulus, according to the different pathological types, the involvement of glomerular sites is also different, such as micro lesions mainly involve the podocytes, thylakoid proliferative glomerulonephritis mainly involves the thylakoid cells and stroma, and membranous nephropathy mainly involves the basement membrane. In the advanced stage of glomerulonephritis, it can also affect the renal tubules and renal interstitium. Secondary glomerulonephritis will have extra-renal manifestations in addition to glomerular injury, for example, SLE can be manifested as multiple systemic injuries such as skin, joints, nervous system and so on. It is recommended that patients with glomerulonephritis go to the hospital in time, clarify the cause of the disease under the guidance of the doctor, and treat the symptoms in time to avoid delaying the condition.