Unilateral persistent tinnitus may be caused by neurogenic tinnitus, earwax and secretory otitis media. 1. Neurogenic tinnitus: the pathogenesis is not clear, the cause may be multiple factors, long-term noise stimulation, the use of ototoxic drugs, chronic physical diseases, etc., may lead to unilateral persistent tinnitus. 2. Cerumen: Cerumen causes localized blockage, which can also lead to unilateral persistent tinnitus. 3. Secretory otitis media: Inflammatory stimulation causes congestion and swelling of the mucous membrane of the middle ear, and some of them have fluid in the tympanic chamber, which can lead to unilateral persistent tinnitus. 4. Other diseases: Meniere’s disease, as well as the brainstem, auditory cortex nerve fiber lesions, autoimmune diseases, diabetes, hypertension, etc., can also lead to unilateral persistent tinnitus. Unilateral persistent tinnitus, there may be other causes, need to go to the hospital in time to check, clear cause.