A little cold is mainly considered upper respiratory tract infection, it is possible to do nucleic acid test, and the cold does not affect the nucleic acid test results. When a patient has a cold, it is mainly due to viral or bacterial stimulation of the respiratory mucosa, causing mucosal edema, manifested as nasal congestion, cough, runny nose and other discomforts. The nucleic acid test belongs to the new coronavirus test, when the patient is infected with the new coronavirus pneumonia, there will be a positive result, when the patient appears to have a cold, do the nucleic acid test will not affect the results of the nucleic acid test. Patients should try to have an empty stomach before having the nucleic acid test, avoid overfilling, avoid drinking a lot of water, and minimize vomiting due to pharyngeal and nasal irritation. When patients have a cold, they should drink plenty of water and rest to promote recovery from the cold.