Perifollicular keratosis is a chronic follicular keratinizing skin disease with unknown etiology and pathogenesis, possibly related to autosomal dominant inheritance, vitamin A deficiency, and metabolic disorders. Acid resurfacing for perifollicular keratosis is useful. Perifollicular keratosis usually does not affect the patient’s health and does not require treatment. Acid brushing skin resurfacing is a medical cosmetic procedure that speeds up the metabolism of the facial skin by applying chemical exfoliating medications, such as fruit acids and salicylic acid, to the skin to promote the shedding of aged keratinocytes from the skin on the surface of the face and the production of a new layer of keratinocytes. Patients suffering from keratosis pilaris can use the brushing acid resurfacing technique to improve the condition of their skin, but they need to be treated appropriately under the guidance of a medical professional. After the treatment, it may produce redness, swelling, pain and other discomforts on the skin, which need to be improved according to the symptoms and, if necessary, under the guidance of a doctor. Acid resurfacing for perifollicular keratinization is useful, but it needs to be performed in a regular medical facility after a hospital visit.