Fluoxetine, also known as Benadryl, is one of the first selective 5-hydroxytryptamine reuptake inhibitors to be marketed and has an important role in antidepressant treatment. Fluoxetine, a selective 5-hydroxytryptamine reuptake inhibitor, can treat not only depression, but also eating disorders and obsessive-compulsive disorder, and has a significant reuptake inhibitory effect on 5-hydroxytryptamine. It also has an effect on the reuptake of NE receptors, or norepinephrine, which can regulate appetite and feeding, but may also cause anxiety after euphoria. In particular, fluoxetine has a strong effect on 5-hydroxytryptamine 2C receptors and has some activating effect, so it is more likely to cause anxiety problems than other selective 5-hydroxytryptamine reuptake inhibitors. Fluoxetine is currently the only selective 5-hydroxytryptamine reuptake inhibitor approved for the treatment of eating disorders, so this drug is very good, especially in clinical use, the treatment range is relatively wide. However, it is important to listen to the doctor’s arrangement in person, because this drug also has certain side effects, such as causing anxiety and insomnia, and if improperly used, it may also turn into manic episodes, which need to be noted.