If a patient with a cerebral infarction is still getting worse after being hospitalized, it means that the patient has a progressive stroke. Progressive stroke is a special type of stroke that causes exacerbations mainly due to multiple reasons. If the patient is older and has underlying diseases such as high blood glucose, poor blood pressure control and poor vascularity, the patient’s condition may worsen within 1-2 days after the initial stroke, even after hospitalization, which is called progressive stroke. For the prevention of progressive stroke, it is important to strengthen the control of the underlying disease in the early stage. If the patient’s blood glucose or blood pressure is unstable, it must be well controlled by using anti-platelet aggregation drugs, anticoagulation drugs if necessary, and blood pressure should not be controlled too low. A comprehensive intervention can minimize the risk of re-aggravation of stroke after hospitalization.