1, diabetes When people are fat to a certain extent, muscle and fat will be insensitive to insulin, that is, the phenomenon of insulin resistance. At this point, the pancreatic islet cells will secrete more insulin to fight this phenomenon. After about several years to decades, the overworked islet cells will fail and develop diabetes. 2, sleep apnea syndrome A large amount of fat accumulation is likely to cause daytime drowsiness, poor sleep at night, and snoring, edema and even breathing difficulties, and other symptoms, and in serious cases will lead to “sleep apnea syndrome”. 3, coronary heart disease epidemiological survey shows that obesity is one of the independent risk factors leading to the development of coronary heart disease, it will also increase the incidence of heart attack, stroke. 4, hypertension obesity is the most common comorbidity is hypertension. A survey in the United States pointed out that more than the standard weight of 15 kilograms of people, 30% suffer from hypertension. 5, hyperlipidemia Most obese patients with fat metabolism disorders, hypercholesterolemia, hypertriglyceridemia, etc.. Hyperlipidemia will trigger coronary heart disease, myocardial infarction, cerebral thrombosis and other cardiovascular diseases at any time, known as “silent killer”. 6, fatty liver caused by obesity and fatty liver will lead to liver cirrhosis, liver cancer. And cause diabetes, hypertension, coronary heart disease and other diseases. 7, osteoarthrosis waist, leg, shoulder and back pain, and even cause joint deformation, seriously affect limb activities. 8, gout Due to obesity caused by protein metabolism disorder, body protein metabolism abnormal, resulting in high body uric acid, high purine, the formation of toe, leg joint pain.