Kidney transplantation, which is often referred to as kidney transplantation, has bad effects including rejection reaction, infection, drug reaction, early renal insufficiency and so on. 1. As patients receive other people’s kidneys, they will have chronic rejection reaction, and some of them will suffer from recurrent increase of urine protein, localized emaciation and lower limb edema. 2. As kidney transplantation is considered a major surgery, immunity will be lowered after the operation, and the wound may be infected if it is not handled well. After the operation, we should pay attention to clean the wound, pay attention to light diet, but need to have enough nutrition to improve immunity and avoid infection. 3. Drug reaction: most patients need to take oral immunosuppressant for a long time after the operation, which will lead to the damage of liver and kidney function, and the long-term use of hormones such as prednisolone, which will lead to osteoporosis and so on. 4. After kidney transplantation, if you still can’t restore the original kidney function, you will also have early renal insufficiency, which will lead to renal failure in serious cases.