Hand eczema blisters (blisters) itch can choose antihistamines, glucocorticosteroids, immunosuppressants and other drugs, but due to individual differences, there is no absolute efficacy of the drug, according to their own actual situation in the doctor’s advice to choose reasonably. 1. antihistamine drugs: eczema on the hands is generally associated with genetics, immune abnormalities, endocrine and metabolic disorders, chronic inflammation, dietary habits and other factors, belonging to a chronic inflammatory itchy disease, can be recommended by the doctor to choose antihistamines to improve the itching of the skin, such as benzydamine hydrochloride tablets, cyproheptadine tablets cetirizine tablets, and so on. 2. Glucocorticoid drugs: such as halometasone cream, compound dexamethasone acetate cream for anti-inflammatory treatment. 3. Immunosuppressants: such as methotrexate, cyclosporine capsules and other immunosuppression to regulate the body’s immune. When the hand eczema blisters and accompanied by itching, according to their own actual situation, in the doctor’s advice under the reasonable choice of drugs, to avoid unauthorized abuse of drugs.