Antidepressants usually have few adverse effects on sexual function, but long-term medication may cause sexual dysfunction, including loss of libido, delayed ejaculation, and frigidity. The main reason for this is that antidepressants block the 5-hydroxytryptamine transporter, causing sexual dysfunction. The drugs that have sexual function problems in the current situation are paroxetine, sertraline, fluvoxamine, citalopram, and escitalopram. Relatively speaking, fluoxetine has a relatively small effect on sexual dysfunction and has a low probability of occurrence. But the above drugs may have specific situations that need to be analyzed, especially for each patient taking the effect and the role of treatment are not the same. Only active treatment and individualized medication can effectively circumvent the effects of sexual function.