Primary trigeminal neuralgia is preferred to be treated with medication, and other methods will be considered when medication is ineffective. The following four medications are commonly used for drug treatment: 1. Carbamazepine, which is the drug of choice for primary trigeminal neuralgia, with an effective rate of 80%. Patients should start with a small dose, gradually increase the dose, and maintain it with a dose that can control the symptoms to minimize adverse reactions. The drug may cause liver function impairment, aplastic anemia, rash, dizziness, ataxia, dyspepsia, etc. 2, phenytoin sodium, the drug side effects, easy to produce dizziness, ataxia, nystagmus. The effective interval and the toxicity interval are very close to each other, and have been used less frequently.3, gabapentin, this drug is also from a small dose to gradually increase the dose, but need to be added to a larger dose in order to control the symptoms, the side effects are relatively few, mainly drowsiness, dizziness, walking unsteady, etc. 4, pregabalin, this drug is now more recommended for use, with fewer adverse reactions, but the price is more expensive.