New breakthrough in interventional treatment for advanced gastric cancer

       Gastric cancer is difficult to treat and has a poor prognosis, especially for patients in advanced stages. Recently, a team led by Professor Li Maoquan from the Department of Interventional Medicine of the Tenth People’s Hospital of Tongji University has conducted a series of interventional studies on advanced gastric cancer and achieved remarkable efficacy, and the results of the study have been published in the famous foreign journal Anti-Cancer Drugs. The study was conducted using 5-fluorouracil (5-FU) 1000 mg/m2, cisplatin (DDP) 50 mg/m2 and mitomycin C (MMC) 10 mg/m2, the new optimized FCM regimen, as the first-line intra-arterial chemotherapy, repeated every six weeks, with good results. It had a treatment efficacy rate of 95.9%, a definite efficacy rate of 65.3% (95% CI, 52.0-78.6%), an overall survival time of 14.5 months (95% CI, 12.0C17.0 months), a 1-year survival rate of 55.1% and a 2-year survival rate of 18.4%. The main side effects of the treatment were mild gastritis and reduced white blood cells.       It is reported that the team utilized advanced interventional minimally invasive treatment techniques to access the arterial blood vessels through the skin under the surveillance of TV equipment, and delivered the slim catheter to deliver chemotherapy drugs directly to the nutritive vessels of gastric cancer, providing direct killing effect on cancer cells. This method is 400~1000 times more concentrated than traditional intravenous infusion chemotherapy, so the efficacy is greatly improved and the systemic toxic side effects are less. Moreover, no incision and stitches are needed, and the patient can get out of bed the next day and be discharged from the hospital in 3~5 days. This method is especially suitable for patients who have lost the chance of surgery, or for adjuvant and consolidation treatment before and after surgery. Prof. Li’s research results concluded that direct infusion of appropriate chemotherapeutic drugs into the arteries supplying gastric cancer by an interventional method can significantly prolong the survival of gastric cancer patients.       This research result has been recognized by domestic and foreign colleagues and has been widely used in the treatment of gastric cancer, which is believed to benefit more gastric cancer patients.