The possibility of sudden death after staying up all night, but not all people after staying up all night with vague pain in the heart will occur sudden death. After staying up all night heart pain may be due to insufficient blood supply to the coronary arteries, resulting in myocardial temporary ischemia and hypoxia caused by angina pectoris, if the duration of a short period of time, the degree of pain is relatively light, generally in the improvement of lifestyle, pay attention to the rest can be improved, if the duration of a long period of time, the degree of pain is more serious and is accompanied by sweating, nausea and vomiting, etc., it is possible that myocardial infarction or malignant arrhythmia, may be the case. Sudden death is possible at this time. If the patient repeatedly has a vague pain in the heart after staying up all night, it is recommended to go to the hospital in a timely manner, according to the doctor’s advice to carry out electrocardiograms, coronary CTA and other tests to clarify the diagnosis, and then follow the doctor’s advice to actively carry out the treatment.