Cranial defect is a very common disorder in neurosurgery clinic, which often can be caused by traumatic injuries such as traffic accidents, production safety accidents, falling from height, etc., or left behind by intracranial tumors, cerebral hemorrhage, and other cranial brain diseases themselves after craniotomy. The harm of cranial defects lies in the destruction of the integrity of the skull, the closure of the cranial cavity and the stability of the intracranial environment, thus causing cerebrospinal fluid circulation, blood circulation disorders, affecting the normal operation of the nerve function, resulting in a series of neurological symptoms. Some patients may show dizziness, headache, limb weakness, poor fine activities, vision, emotional instability, irritability and so on. Therefore, it is necessary to perform cranial bone repair surgery as early as possible and choose the appropriate repair material for cranial bone repair. With the advancement of medicine, there are more and more cranial repair materials available for use. Plexiglass, light apatite and calcium phosphate bone cement materials, which were once used in clinical practice, are no longer used due to their many clinical complications. Nowadays, the commonly used cranial bone repair material is titanium mesh, which is also a high-quality material that has been used for a long time with good results. However, the metal properties of titanium mesh often bring patients localized skin burning injury due to heat conduction, titanium allergy leading to titanium plate exposure, and localized trauma leading to titanium plate depression and other consequences. In the efforts of medical researchers, a new type of cranial bone repair material: polyether ether ketone (PEEK), for cranial defect repair, it is hereby recommended that patients use PEEK material to repair the cranium, its thermal insulation, strength hardness, elasticity and so on are comparable to the autologous cranial bone, PEEK material as a cranial bone repair material can be used in conjunction with the 3D printing technology to perfectly restore the cranial bone’s anatomical structure, accurately anastomosis of the defective area, it is the It is the best choice for cranial bone repair patients.