Central hyperthermia is one of the more common critical illnesses of stroke and is mainly caused by damage to the subthalamic heat sink. It is mostly seen in thalamic, brainstem and ventricular hemorrhage, as well as brainstem infarction, and also commonly in brain herniation, and is often a midline symptom of stroke. 1. Central hyperthermia of stroke Clinical features: (1) Hyperthermia lasting 39-40 degrees C, high trunk skin temperature but not high limb temperature, no sweating. (2) Antipyretic and analgesic agents cannot lower the temperature. (3) No chills and no other signs of infectious toxicity, no blood changes of infection. (4) Central hyperthermia is often accompanied by other subthalamic symptoms, such as stress ulcers, elevated blood glucose and proteinuria. (2) Central hyperthermia in stroke (1) Etiological treatment: active treatment of stroke, management of brain herniation, etc. (2) Symptomatic treatment: Physical hypothermia. Dopamine receptor agonists: such as bromocriptine 3.75-15mg/d orally in divided doses. Appropriate supplementation of divalent iron ions, in combination with bromocriptine, helps to reduce hyperthermia because divalent iron ions are cofactors of complexine hydroxylase in the process of dopamine synthesis. Nifurtimox: 0.8-2.5mg/kg, intramuscular or intravenous, q6-12h, change to 100mg intramuscular after remission, every other day, maintain for several days.