Differential pressure refers to the difference between systolic pressure and diastolic pressure, also known as pulse pressure difference. A pulse pressure difference of more than 50 belongs to the increase of pulse pressure difference, which may be related to atherosclerosis, anemia, strenuous exercise and other reasons, and may lead to dizziness, insufficient blood supply, angina pectoris, and so on. 1. Causes: ageing, easy to atherosclerosis, causing high pressure is high, low pressure is low, resulting in a large pulse pressure difference, if suffering from anemia, resulting in insufficient blood supply, there will also be a large pulse pressure difference, strenuous exercise, tissue oxygen consumption increases, resulting in vascular diastole and resistance to reduce, there may also be a large pulse pressure difference. 2. Hazard: If you suffer from high blood pressure and have a large differential pulse pressure, applying antihypertensive drugs may lead to even lower low pressure, resulting in headaches, dizziness and other manifestations. If you continue to have a large differential pulse pressure, insufficient blood supply to the organs may occur, and insufficient blood supply to the coronary arteries, which may cause angina pectoris in severe cases. If the pressure difference is greater than 50, it is recommended to go to the hospital in time for examination, to clarify the cause of the disease, active treatment, and control salt intake, avoid strenuous exercise, pay attention to more rest.