A diagnosis of cervical intraepithelial neoplasia (i.e., CIN) grade 3 on colposcopic multipoint biopsy is not necessarily a diagnosis in the final pathologic sense. Technically, colposcopic multi-point biopsy does not fully define the extent and depth of cervical lesions and requires a full assessment by conization. Clinically, some patients with CIN3 are reluctant to undergo conization and wish to undergo direct hysterectomy, believing that this will be less painful and less costly. In fact, if hysterectomy is rushed without conization, the scope of surgery is just right for cervical carcinoma in situ, stage IA1 in early cervical cancer. However, for patients with pathological diagnosis of stage IA2 or IB1, hysterectomy alone is clearly inadequate. Patients with stage IA2 or IB1 need to undergo an extended hysterectomy, which requires the removal of some parametrial tissue. Therefore, colposcopic cervical biopsy for CIN3 requires first a conical hysterectomy (conization), and the next treatment plan is determined based on the pathology of the conization. Only then can the correct and appropriate scope of surgery be ensured. CIN3 is a precancerous lesion with the potential to develop into cervical cancer and needs to be treated aggressively. In the UK, 10 times more patients were diagnosed with CIN3 (including carcinoma in situ) than invasive carcinoma in 2003. Most invasive cancers do not develop and have been diagnosed and managed at the precancerous stage, especially at CIN3, saving many women’s lives. Therefore CIN3, although a precancerous lesion, still needs to be treated aggressively. For those with colposcopic biopsies reporting carcinoma in situ, not excluding infiltration or unclear depth of infiltration, conization is also needed to determine the depth of infiltration.