Systemic lupus erythematosus in young children can last a lifetime. Systemic lupus erythematosus (SLE) is an autoimmune disease of the connective tissues throughout the body that invades multiple systems and organs. Symptoms such as rash, fever, joint swelling and pain, muscle aches and weakness are common. There is no treatment for SLE in young children that can achieve a complete cure. The principle of treatment is early, standardized and individualized treatment to maximize the improvement and delay of organ damage in young children, minimize the adverse effects of drugs (e.g., glucocorticosteroids and immunosuppressants, etc.), reduce the impact on the growth and development of young children, and at the same time need to strengthen the follow up, to improve the prognosis of SLE patients in young children. The short-term treatment of SLE in young children is aimed at controlling the disease as early as possible, improving the clinical symptoms, and minimizing the damage of the disease to the young children’s bodies, while the long-term treatment is aimed at alleviating the disease, preventing and reducing the recurrence of the disease, preventing and controlling the organ damage and complications caused by the disease and the medication, lowering the death rate, and improving the quality of life of the patients with SLE in young children.