Gray nails, also called nail fungus disease, are caused by fungal infection. There is no medicine with particularly good clinical penetration, and the treatment mainly includes topical application, oral antifungal drugs, and laser, photodynamic or nail extraction surgery if necessary. 1. Topical medication: If less than 50% of the nails are damaged at the distal end, less than 4 nails are involved, or if the patient cannot tolerate oral medication, topical antifungal medication, such as cycloheximide or amorphophallus, can be given to inhibit or kill the fungus. 2. Oral medication: If there are many nails involved, topical medication can be combined with oral antifungal medication, including itraconazole, terbinafine hydrochloride, etc., which can inhibit or kill the fungus. 3. Other treatments: other treatments include laser, photodynamic, ionic introduction therapy, etc., which can be used as auxiliary treatment or alternative treatment options. 4. Surgical treatment: Nail extraction can remove the diseased fingernail or toenail, which can achieve the effect of treatment. The specific treatment is decided by the doctor, and medication is still needed after nail extraction. Changes in the shape, color and texture of the fingernails or toenails, it is recommended to go to the dermatology department of the hospital to find out the cause of the disease and target treatment, and the specific medication should follow the doctor’s instructions.