The choice between montelukast sodium and cetirizine is neither good nor bad, but depends on the child’s symptoms and any relevant contraindications. Montelukast sodium is a selective leukotriene receptor antagonist. It is used for the prophylaxis and long-term treatment of asthma. Also used for prophylaxis and maintenance treatment of aspirin asthma, allergic asthma and prevention of exercise asthma. Used in seasonal allergic rhinitis to reduce symptoms. Contraindicated in people who are allergic to this product. Use with caution in pregnant and lactating women. It is well tolerated with mild adverse effects and usually does not require termination of therapy. Cetirizine hydrochloride is a selective histamine H₁ receptor antagonist. It is used for seasonal or perennial allergic rhinitis, urticaria, pruritus, eczema, hay fever and bronchial asthma caused by allergens. It is contraindicated for those who are allergic to the product. Use with caution in pregnant and lactating women and children less than 12 years of age. Adverse reactions are mild and transient, including drowsiness, somnolence, headache, dizziness, dry mouth and gastrointestinal discomfort. The two drugs have their own indications and contraindications, and there are certain adverse reactions, the specific choice of which drug need to follow the doctor’s instructions.