Hands peeling serious may be cracked hands and feet, ringworm, eczema and other causes, according to the cause of different, can choose to use moisturizing cream, anti-fungal drugs, glucocorticoid drugs. 1. Cracked hands and feet: occurring in winter, flaking accompanied by cracking, can be improved with moisturizing cream, or topical urea ointment, vitamin E milk and other treatments. 2. Ringworm: positive fungal examination can be diagnosed, preferred antifungal treatment, can be used externally with antifungal ointment, commonly used ketoconazole cream, terbinafine cream and so on. 3. Hand eczema: manifested as symmetrical erythema of hands, flaking, etc., can be used externally with glucocorticoid drugs, mometasone furoate cream, halometasone cream, etc.. If the hands and feet peeling serious, should go to the regular hospital, according to the different causes, choose the appropriate treatment. The specific use of drugs need to follow the doctor’s instructions.