Cisplatin side effects include kidney damage, tinnitus, hearing impairment, and peripheral neuropathy. Cisplatin is an anti-tumor drug, suitable for chemotherapy of ovarian cancer, bladder cancer, etc. The use of the drug may cause a variety of side effects. The most important one is renal function damage, and it can also cause tinnitus, treble hearing loss, peripheral neuropathy, bone marrow suppression, nausea, vomiting, hyperuricemia, electrolyte disorders, allergic reactions and so on. The occurrence of side effects is related to the dosage of the drug and individual reactivity. Cisplatin is contraindicated in patients with platinum drug allergy, pregnant women, lactating women, renal insufficiency, and patients with hearing impairment and bone marrow suppression. Physicians should pay attention to observe the patient’s reaction and monitor the relevant indexes during the use of the drug, if the patient has obvious adverse reactions after the use of the drug need to stop the drug and carry out the appropriate treatment in a timely manner.