The side effects of spironolactone mainly include hyperkalemia, gastrointestinal reaction, allergy, etc., which can be treated by stopping the drug or combining with furosemide diuretic and omeprazole gastric protection. 1. Spironolactone is a kind of potassium-preserving diuretic, when taking spironolactone to treat edematous diseases, non-potassium-preserving diuretics, such as furosemide, can be used in combination to prevent the occurrence of hyperkalemia, but the treatment still needs to monitor the situation of blood electrolytes, to prevent the emergence of low-potassium blood and hyperkalemia, in order to deal with it in time. 2. Some patients taking spironolactone or gastrointestinal reactions, such as nausea, vomiting, etc., can be added with stomach protector (such as omeprazole) with the use of most of the symptoms will be weakened or disappear, serious cases need to stop the drug treatment. 3. When allergic reactions such as skin rash occur after consuming spironolactone, the use of spironolactone can be continued and antihistamines (such as loratadine) can be added for mild cases, while the drug needs to be discontinued for serious cases. The most common side effect of spironolactone is hyperkalemia, the use of blood electrolytes must be monitored, other side effects are relatively rare, but still need to pay attention to, the emergence of discomfort in a timely manner to seek medical treatment.