Vulvar leukoplakia may be malignant, but not everyone is malignant. The time limit for malignant transformation is uncertain, it can be 1-2 years, or up to more than 10 years, or even life-long non-cancerous. Therefore, patients with vulvar leukoplakia should follow up regularly, and go to gynecology department of the hospital for treatment in a timely manner if abnormalities are found, and if cancerous transformation is detected, it should be treated with surgery in a timely manner. Vulvar leukoplakia is caused by many factors, which are related to local bacterial and viral stimulation as well as immunity factors and malnutrition. After the occurrence of vulvar leukoplakia, women may have itchy skin, thinning and drying of mucous membrane, which need to be treated with Chinese medicine fumigation or ointment. Women should keep the vulva clean, dry and hygienic, eat more vegetables and fruits rich in vitamins and trace elements, enhance the body’s immunity and resistance, and avoid high-risk sex, which is conducive to the alleviation of leukoplakia vulvae.