Painkillers are usually taken at the time of pain, and as far as possible can be chosen to be taken after meals. Painkillers usually refer to medications that relieve the body of pain. Common painkillers include ibuprofen extended-release tablets and morphine hydrochloride tablets. When used for pain relief, they need to be taken at the time of pain. When the pain is severe, the dosage can be increased as directed or as prescribed by the doctor. Since pain medications may cause adverse reactions in the stomach and intestines, but diet does not have a significant effect on the effectiveness of the medication, they can be taken with meals. Common adverse reactions to both pain medications include nausea, abdominal pain, vomiting, and occasional shock, gastrointestinal bleeding, and acute renal failure with ibuprofen extended-release tablets. Morphine hydrochloride tablets occasionally see respiratory depression, coma, blood pressure drop, etc. When serious adverse reactions, should immediately seek medical attention. It should be noted that people who are allergic to both drugs are prohibited from taking them. Patients suffering from severe blood abnormalities, peptic ulcers, as well as pregnant and lactating people are prohibited from taking ibuprofen extended-release tablets. Morphine hydrochloride tablets are prohibited in patients with increased intracranial pressure, craniocerebral injuries, pulmonary embolism, as well as in children, pregnant women and other groups. Strictly follow the doctor’s instructions before use.