Patient: description of the condition (onset time, main symptoms, hospital, etc.): I got this disease at the age of five or six, there are more than 20 years, when the palms of the hands and feet have hard blisters. Later, with hormones or something more and more serious, developed into a whole body piece by piece, almost good is into the map, this year the most serious back of the hand are, I know and mood have a relationship with this kind of that to the good mood of the size of the hospital have seen herbal medicine western medicine have eaten topical medicine also smear I want to know this years there is no new progress can let me see hope.