Amoxicillin can be taken for toothache if the patient does not have a history of penicillin allergy themselves. Amoxicillin is a better anti-inflammatory drug, but it is mainly suitable for infections between the roots of the teeth and wisdom teeth pericoronitis. In the case of acute pulpitis, the use of anti-inflammatory drugs such as amoxicillin is usually not very effective, and the pain will gradually continue to worsen. For acute pulpitis, do not carry out routine anti-inflammatory, must promptly go to the dentist, let the doctor for the tooth to open the pulp drainage, and then through the routine root canal treatment can eliminate the pain, and even in the process of treatment is not required to take anti-inflammatory drugs. Only when the inflammation of the root spreads beyond the periapical area, forming a swelling of the face, or wisdom tooth obstruction causes inflammation only need to carry out anti-inflammatory treatment.