Itching on one side of the thigh may be physiological or pathological, such as eczema, hives, etc. Physiological reasons need to adjust the lifestyle, pathologically caused by the need for targeted treatment under the guidance of the doctor, such as drug therapy. 1. Physiological: if the skin is dry, or too many baths, bath water is too hot may cause itching. Patients should avoid excessive cleaning, and use moisturizer to repair the skin barrier if necessary. 2. Eczema: the lesions have more forms, which can be papules, erythema, blisters, papules, etc., accompanied by intense itching. In the acute stage (with blisters, vesicles, oozing), it is recommended to use boric acid solution wet compresses; in the subacute stage, zinc oxide paste can be used; in the chronic stage, it is recommended to use topical glucocorticoid ointment. 3. Urticaria: the whole body can appear wind, accompanied by obvious itching; can also be confined to a certain part, resulting in an itch on the side of the thigh. Second-generation antihistamines are generally preferred, such as fexofenadine and loratadine. In addition to the above factors, there are many other factors that can cause itching on one side of the thigh, so it is important to go to the hospital in a timely manner to clarify the cause of the disease, and follow the doctor’s instructions to standardize the use of medication.