It is possible to take painkillers for tooth extraction. However, patients need to distinguish whether the pain is physiological or pathological. Generally speaking, in the case of extraction of more traumatic teeth, such as buried and obstructed wisdom teeth, the operation involves the incision and flap of the gums, the debridement and division of the teeth, there will be physiological pain after the operation, and this pain may be more intense. In this case, you can take some pain medications as appropriate, generally the first step of pain relief drugs, such as ibuprofen, acetaminophen, aspirin, celecoxib and so on. However, if the pain is not of this kind, but is more than 3 days after the tooth extraction, the pain of the extraction wound suddenly appears. It is necessary to check whether there is redness, swelling and pus in the extraction wound and whether there is a bad smell in the mouth, because it is possible that the pain is not just post-operative, but there is a pathological post-operative infection, which cannot be cured by taking painkillers.