The common reasons for waking up with a sore throat in the morning are acute pharyngitis, reflux pharyngitis and sinusitis. 1. Acute pharyngitis: mostly due to bacterial and viral infections. Inflammatory mediators can cause congestion, swelling and damage to the mucous membranes of the oropharynx and laryngopharynx, which in turn cause sore throat, difficulty swallowing, coughing and other symptoms. So it can cause a sore throat in the morning. 2. Reflux pharyngitis: it is usually caused by the patient’s reflux gastritis, and the reflux material stimulates the throat area at night during sleep. The reflux can cause damage to the mucous membrane in the throat area, which then manifests itself as a sore throat and a feeling of obstruction in the throat. 3. Sinusitis: It can lead to symptoms of nasal congestion. The nasal cavity is not ventilated during sleep, the patient is easy to open the mouth to breathe, and then get up in the morning there will be a dry mucous membrane in the throat, resulting in a sore throat. Wake up in the morning with a sore throat, it is recommended to go to the regular hospital in time, systematic examination to clarify the cause of the disease.