Pentavalent rotavirus vaccine is necessary as the most effective means of preventing rotavirus enteritis. Rotavirus infectious diarrhea is a serious disease, second only to respiratory infections in terms of emergency room visits and death rates in children, and rotavirus vaccination is an effective as well as cost-effective means of reducing the incidence of severe diarrhea. Fall is the most common time of the year for diarrhea in children, so it is recommended that children be vaccinated with the pentavalent rotavirus vaccine in September. Pentavalent rotavirus vaccine is relatively safe and most children have no adverse reactions to the vaccine, while a small number of children may have adverse reactions, such as mild diarrhea, vomiting, and fever, which can usually be relieved on their own. There are certain contraindications to vaccination with the pentavalent rotavirus vaccine, which should be administered under the guidance of a specialist.