Bone marrow transplantation for leukemia should be selected at the best time according to the patient’s condition, and is generally best performed when the patient’s condition is in complete remission and the patient’s general condition is good. Bone marrow transplantation is a therapeutic method of replacing abnormal hematopoietic stem cells by feeding normal hematopoietic stem cells into the patient’s body through a vein. It is commonly used in the treatment of refractory or relapsed leukemia, primary acute leukemia that is difficult to survive non-transplantation, and chronic lymphocytic leukemia. The efficacy of bone marrow transplantation after the first remission period is mostly better than that of the second remission period. Bone marrow transplantation requires strict physical conditions of the patients, and they need to be fully evaluated and prepared before undergoing bone marrow transplantation. The transplantation should be performed at the optimal time point to increase the success rate of the transplantation and to reduce the chances of complications, and the patients should pay attention to the regular checkups after the transplantation. The optimal time for leukemia transplantation is recommended to be evaluated by a specialist.